Journal
MARINE DRUGS
Volume 11, Issue 5, Pages 1718-1727Publisher
MDPI AG
DOI: 10.3390/md11051718
Keywords
Xylariaceae sp.; polyketide; enzyme-inhibitory activity; antifouling activity
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Funding
- 973 Program of China [2010CB833803]
- 863 Program of China [2012AA092104]
- National Marine Public Welfare Research Project of China [201305017]
- National Natural Science Foundation of China [40931160435, 40976090]
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Eighteen polyketides (1-18) including six citrinin derivatives, two phenol derivatives, one cyclopentenone, two naphthol derivatives, and seven tetralone derivatives were isolated from the culture broth of a marine-derived fungal strain Xylariaceae sp. SCSGAF0086. Five of these compounds (1, 2, 8, 9, and 10) were new, and their structures were determined by spectroscopic methods. Compounds 4, 6, 7, and 17 showed enzyme-inhibitory activities towards several tested enzymes, and 6 and 7 showed strong antifouling activity against Bugula neritina larvae settlement. This is the first time that the antifouling and enzyme-inhibitory activities of these compounds has been reported.
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