Journal
MARINE DRUGS
Volume 11, Issue 2, Pages 551-558Publisher
MDPI AG
DOI: 10.3390/md11020551
Keywords
Chondrostereum sp.; sesquiterpenoids; chondrosterins; marine fungus; cytotoxic activities
Categories
Funding
- National Natural Science Foundation of China [30973633, 20502036]
- Guangdong Provincial Science and Technology Research Program [2012A031100005, 2010B030800002, 2010B030600011]
- Guangdong Natural Science Foundation [S2012010010653]
- Guangzhou Science and Technology Research Program [2011Y1-00036]
- Fundamental Research Funds for the Central Universities [11lgpy09]
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The marine fungus Chondrostereum sp. was collected from a soft coral of the species Sarcophyton tortuosum from the South China Sea. Three new compounds, chondrosterins F-H (1, 4 and 5), together with three known compounds, incarnal (2), arthrosporone (3), and (2E)-decene-4,6,8-triyn-1-ol (6), were isolated. Their structures were elucidated primarily based on NMR and MS data. Incarnal (2) exhibited potent cytotoxic activity against various cancer cell lines.
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