Journal
MARINE DRUGS
Volume 11, Issue 3, Pages 800-816Publisher
MDPI
DOI: 10.3390/md11030800
Keywords
marine natural product; azaphilone; pentaketide; Bartalinia robillardoides; Tethya aurantium
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Funding
- Ministery of Science, Economic Affairs and Transport of the State of Schleswig-Holstein (Germany)
- European Union (EFRE)
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Microbial studies of the Mediterranean sponge Tethya aurantium led to the isolation of the fungus Bartalinia robillardoides strain LF550. The strain produced a number of secondary metabolites belonging to the chloroazaphilones. This is the first report on the isolation of chloroazaphilones of a fungal strain belonging to the genus Bartalinia. Besides some known compounds (helicusin A (1) and deacetylsclerotiorin (2)), three new chloroazaphilones (helicusin E (3); isochromophilone X (4) and isochromophilone XI (5)) and one new pentaketide (bartanolide (6)) were isolated. The structure elucidations were based on spectroscopic analyses. All isolated compounds revealed different biological activity spectra against a test panel of four bacteria: three fungi; two tumor cell lines and two enzymes.
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