Journal
MARINE DRUGS
Volume 11, Issue 1, Pages 114-123Publisher
MDPI
DOI: 10.3390/md11010114
Keywords
spatane diterpenoid; soft coral; Sinularia leptoclados
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Funding
- National Science Council of Taiwan [NSC 98-2313-B-276-001-MY3, NSC 101-2313-B-276-002]
- Antai Medical Care Cooperation Antai Tian-Sheng Memorial Hospital Research Fund [101-FI-DBS-IAC-R-002]
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A new spatane diterpenoid, leptoclalin A (1), along with two previously reported known norcembranoid diterpenes (2 and 3), were isolated from a cultured soft coral Sinularia leptoclados. The structures were determined by extensive spectroscopic analyses and by comparison with the spectral data of related known compounds. Metabolite 1 is rarely found in spatane skeletons reported from soft corals. In addition, compound 1 exhibited weak cytotoxicity towards human tumor cell lines T-47 D and K-562.
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