Journal
MARINE DRUGS
Volume 10, Issue 1, Pages 200-208Publisher
MDPI
DOI: 10.3390/md10010200
Keywords
marine sponges; aurantosides; antifungal; tetramic acid glycoside; Melophlus sp.
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Funding
- U.S. National Institutes of Health [NIH ICBG U01-TW007401]
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A new tetramic acid glycoside, aurantoside K, was isolated from a marine sponge belonging to the genus Melophlus. The structure of the compound was elucidated on the basis of spectroscopic analysis (H-1 NMR, H-1-H-1 COSY, HSQC, and HMBC, as well as high-resolution ESILCMS). Aurantoside K did not show any significant activity in antimalarial, antibacterial, or HCT-116 cytotoxicity assays, but exhibited a wide spectrum of antifungal activity against wild type Candida albicans, amphotericin-resistant C. albicans, Cryptococcus neoformans, Aspergillus niger, Penicillium sp., Rhizopus sporangia and Sordaria sp.
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