Journal
MARINE DRUGS
Volume 10, Issue 10, Pages 2300-2311Publisher
MDPI
DOI: 10.3390/md10102300
Keywords
marine natural product; deep-sea hydrothermal vent; drug discovery; induction of apoptosis; bacteria; computational methods
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Funding
- Rutgers University through an Academic Excellence award
- NSF [OCE 03-27373, MCB 04-56676, MCB 08-43678]
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Chemical and biological investigation of the cultured marine hydrothermal vent bacterium, Thermovibrio ammonifican led to the isolation of two hydroxyethylamine chromene derivatives, ammonificins C and D. Their structures were elucidated using combination of NMR and mass spectrometry. Absolute stereochemistry was ascertained by comparison of experimental and calculated CD spectra. Biological evaluation and assessment were determined using the patented ApopScreen cell-based screen for apoptosis-induction. Ammonificins C and D induce apoptosis in micromolar concentrations. To our knowledge, this finding is the first report of chemical compounds that induce apoptosis from the cultured deep-sea marine organism, hydrothermal vent bacterium, Thermovibrio ammonificans.
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