Journal
MARINE DRUGS
Volume 10, Issue 3, Pages 521-538Publisher
MDPI AG
DOI: 10.3390/md10030521
Keywords
marine extract; antiviral drug; antiviral activity; enveloped virus; secosteroids
Categories
Funding
- National Institutes of Environmental Health Sciences [P50ES012740]
- National Institutes of Health, the National Science Foundation [OCE04-32479, OCE09-11000]
- National Institute on Minority Health and Health Disparities [G12RR003061]
- National Mega Project on Major Drug Development in China [2011ZX09401-302]
Ask authors/readers for more resources
Marine environments are a rich source of significant bioactive compounds. The Hawaiian archipelago, located in the middle of the Pacific Ocean, hosts diverse microorganisms, including many endemic species. Thirty-eight microbial extracts from Hawaiian coastal waters were evaluated for their antiviral activity against four mammalian viruses including herpes simplex virus type one (HSV-1), vesicular stomatitis virus (VSV), vaccinia virus and poliovirus type one (poliovirus-1) using in vitro cell culture assay. Nine of the 38 microbial crude extracts showed antiviral potencies and three of these nine microbial extracts exhibited significant activity against the enveloped viruses. A secosteroid, 5 alpha(H), 17 alpha(H),(20R)-beta-acetoxyergost-8(14)-ene was putatively identified and confirmed to be the active compound in these marine microbial extracts. These results warrant future in-depth tests on the isolation of these active elements in order to explore and validate their antiviral potential as important therapeutic remedies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available