Journal
MARINE DRUGS
Volume 10, Issue 3, Pages 539-550Publisher
MDPI
DOI: 10.3390/md10030539
Keywords
pimarane diterpenes; marine sediment-derived fungus; Eutypella scoparia; South China Sea; cytotoxic activity
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Funding
- National High Technology Research and Development Program of China (863 Program) [2012AA092104]
- Guangdong Provincial Project for Science and Technology [2011B031200003, 2010B030600010]
- Chinese Academy of Sciences [KSCX2-EW-G-12]
- Guangdong Academy of Sciences Foundation for outstanding young scientists
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Five new oxygenated pimarane diterpenes, named scopararanes C-G (1-5) were isolated from the culture of a marine sediment-derived fungus Eutypella scoparia FS26 obtained from the South China Sea. The structures of these compounds were established on the basis of extensive spectroscopic analysis. The absolute configurations of compounds 1-5, were determined by CD spectroscopic analysis and comparison with literature data. All isolated compounds (1-5) were evaluated for their cytotoxic activities against MCF-7, NCI-H460, and SF-268 tumor cell lines by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H- tetrazolium bromide (MTT) method.
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