Journal
MARINE DRUGS
Volume 10, Issue 7, Pages 1422-1432Publisher
MDPI AG
DOI: 10.3390/md10071422
Keywords
soft coral; Sinularia sp.; polyoxygenated sterols; cytotoxicity
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Funding
- Key Program of National Natural Science Foundation of China [41130858]
- National Natural Science Foundation of China [40976077, 30901879, 41176121, 81172977]
- Program for New Century Excellent Talents in University, Ministry of Education of China [NCET- 11-0472]
- Research Fund for the Doctoral Program of Higher Education, Ministry of Education of China [20090132110002]
- Program for Changjiang Scholars and Innovative Research Team in University, Ministry of Education of China [IRT0944]
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Chemical investigation of the ethanol extract of soft coral Sinularia sp. collected from the South China Sea led to the isolation of three new polyoxygenated sterols, (3S,23R,24S)-ergost-5-ene-3 beta,23 alpha,25-triol (1), (24S)-ergostane-6-acetate-3 beta,5 alpha,6 beta,25-tetraol (2), (24S)-ergostane-6-acetate-3 beta,6 beta,12 beta,25-tetraol (3) together with three known ones (4-6). The structures, including relative configurations of the new compounds (1-3), were elucidated by detailed analysis of spectroscopic data (IR, UV, NMR, MS) and by comparison with related reported compounds. The absolute configuration of 1 was further determined by modified Mosher's method. Compound 5 exhibited moderate cytotoxicity against K562 cell line with an IC50 value of 3.18 mu M, but also displayed strong lethality toward the brine shrimp Artemia salina with a LC50 value of 0.96 mu M.
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