Journal
MARINE DRUGS
Volume 10, Issue 11, Pages 2571-2583Publisher
MDPI
DOI: 10.3390/md10112571
Keywords
Streptomyces caelestis; citreamicin; antibacterial; MRSA
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Funding
- China Ocean Mineral Resources Research and Development Association [DY125-15-T-02]
- King Abdullah University of Science and Technology (KAUST) [SA-C0040/UK-C001]
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Four new polycyclic antibiotics, citreamicin theta A (1), citreamicin theta B (2), citreaglycon A (3), and dehydrocitreaglycon A (4), were isolated from marine-derived Streptomyces caelestis. The structures of these compounds were elucidated by 1D and 2D NMR spectra. All four compounds displayed antibacterial activity against Staphylococcus haemolyticus, Staphylococcus aureus, and Bacillus subtillis. Citreamicin theta A (1), citreamicin theta B (2) and citreaglycon A (3) also exhibited low MIC values of 0.25, 0.25, and 8.0 mu g/mL, respectively, against methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300.
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