Journal
MARINE DRUGS
Volume 10, Issue 3, Pages 627-638Publisher
MDPI AG
DOI: 10.3390/md10030627
Keywords
Chondrostereum sp.; sesquiterpenoids; chondrosterins; marine fungus; cytotoxic activities
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Funding
- National Natural Science Foundation of China [20502036, 20602044, 30973633]
- Guangdong Provincial Science and Technology Research Program [2009B030801190, 2010B030800002, 2010B030600011]
- Guangzhou Science and Technology Research Program [2011308, 2010U1-E00531-5]
- Fundamental Research Funds for the Central Universities [11lgpy09]
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The marine fungus Chondrostereum sp. was collected from a soft coral Sarcophyton tortuosum from the South China Sea. This fungus was cultured in potato dextrose broth medium and the culture broth was extracted with EtOAc. Five new triquinane-type sesquiterpenoids, chondrosterins A-E (1-5), and the known sesquiterpenoid hirsutanol C (6), were isolated. The structures were elucidated mainly on the basis of NMR, MS, and X-ray single-crystal diffraction data. Chondrosterin A (1) showed significant cytotoxic activities against cancer lines A549, CNE2, and LoVo with IC50 values of 2.45, 4.95, and 5.47 mu M, respectively.
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