Journal
MARINE DRUGS
Volume 10, Issue 8, Pages 1799-1811Publisher
MDPI AG
DOI: 10.3390/md10081799
Keywords
Aldisa andersoni; nudibranch mollusc; structural elucidation; feeding-deterrence; growth inhibitory assays
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Funding
- CNR-CSIR Italy-India
- PRIN KFMP7Z (prodotti naturali da molluschi opistobranchi: identificazione di nuovi lead compounds per lo sviluppo di farmaci antitumorali)
- Televie (FNRS, Belgium)
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The first chemical study of the Indo-Pacific dorid nudibranch Aldisa andersoni resulted in the isolation of five chlorinated phenyl-pyrrolyloxazoles belonging to the phorbazole series. Two new molecules, 9-chloro-phorbazole D and N1-methyl-phorbazole A, co-occurring with known phorbazoles A, B and D, have been characterized. Phorbazoles were found to be present mainly in the external part of the mollusc. The structures of the new compounds were determined by interpretation of spectroscopic data, mainly NMR and mass spectrometry and by comparison with the literature data. Evaluation of feeding-deterrence activity as well as in vitro growth inhibitory properties in human cancer cells was also carried out.
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