Journal
MARINE DRUGS
Volume 10, Issue 9, Pages 2023-2032Publisher
MDPI AG
DOI: 10.3390/md10092023
Keywords
Sinularia sp.; cembrane diterpenoids; NF-kappa B inhibitor
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Funding
- National Key Basic Research Program of China (973)'s Project [2010CB833800, 2011CB915503]
- National High Technology Research and Development Program (863 Program) [2012AA092104]
- National Natural Science Foundation of China [30973679, 20902094, 21172230, 41176148, 21002110]
- Knowledge Innovation Program of Chinese Academy of Science [SQ201117, SQ200904, KSCX2-YW-G-073, KSCX2-EW-G-12B]
- Guangdong Province-CAS Joint Research Program [2011B090300023]
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Five new cembrane diterpenoids, named sinuflexibilins A-E (1-5), along with nine other known diterpenoids (6-14), have been isolated from the organic extract of a Hainan soft coral Sinularia sp. Their structures were determined on the basis of extensive spectroscopic analyses and by comparison of their spectral data with those of related metabolites. Compound 13, flexibilide, exhibited significant inhibitory activity of NF-kappa B activation using the cell-based HEK293 NF-kappa B luciferase reporter gene assay.
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