Journal
MARINE DRUGS
Volume 10, Issue 9, Pages 2089-2102Publisher
MDPI AG
DOI: 10.3390/md10092089
Keywords
Plocamium angustum; polyhalogenated acyclic monoterpenes; hyphenated spectroscopy; HPLC-NMR; biological activity
Categories
Funding
- Australian Postgraduate Research Award (APA)
Ask authors/readers for more resources
A combination of on-line HPLC-NMR and off-line chemical investigations has resulted in the identification of the previously reported polyhalogenated monoterpene plocamenone, together with the new structural analogue isoplocamenone from the crude extract of the marine alga Plocamium angustum. On-flow and stop-flow HPLC-NMR analyses (including the acquisition of WET 2D NMR spectra) rapidly assisted in the identification of the major component plocamenone and in the partial identification of its unstable double bond isomer isoplocamenone. Conventional off-line isolation and structural characterization techniques were employed to unequivocally confirm both structures, leading to a structural revision for plocamenone, as well as to obtain sufficient quantities for biological testing.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available