Journal
MARINE DRUGS
Volume 10, Issue 6, Pages 1297-1306Publisher
MDPI
DOI: 10.3390/md10061297
Keywords
marine-derived fungus; Penicillium aurantiogriseum; quinazolin-4-one; antitumor
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Funding
- National Natural Science Foundation of China [30911120483, 81102356, 30901849, 30911120484]
- CAS [XDA04074000]
- Ministry of Science and Technology of China [2011ZX11102-011-11, 2012CB721006, 2007DFB31620]
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Three new alkaloids, including auranomides A and B (1 and 2), a new scaffold containing quinazolin-4-one substituted with a pyrrolidin-2-iminium moiety, and auranomide C (3), as well as two known metabolites auranthine (4) and aurantiomides C (5) were isolated from the marine-derived fungus Penicillium aurantiogriseum. The chemical structures of compounds 1-3 were elucidated by extensive spectroscopic methods, including IR, HRESIMS and 2D NMR spectroscopic analysis. The absolute configurations of compounds 1-3 were suggested from the perspective of a plausible biosynthesis pathway. Compounds 1-3 were subjected to antitumor and antimicrobial screening models. Auranomides A-C exhibited moderate cytotoxic activity against human tumor cells. Auranomides B was the most potent among them with an IC50 value of 0.097 mu mol/mL against HEPG2 cells.
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