Journal
MARINE DRUGS
Volume 10, Issue 6, Pages 1203-1211Publisher
MDPI AG
DOI: 10.3390/md10061203
Keywords
soft coral; eunicellin-based diterpenes; cytotoxicity; Klyxum simplex
Categories
Funding
- Ministry of Education [00C030205]
- National Science Council of Taiwan [NSC 98-2113-M-110-002-MY3, 100-2320-B-110-001-MY2]
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Four new eunicellin-based diterpenes, simplexins P-S (1-4), and the known compound simplexin A (5), have been isolated from the soft coral Klyxum simplex. The structures of the new metabolites were determined on the basis of extensive spectroscopic analysis, particularly 1D and 2D NMR experiments. Compounds 1 and 3-5 were shown to exhibit cytotoxicity against a limited panel of cancer cell lines, 3 being the most cytotoxic.
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