Journal
MARINE DRUGS
Volume 10, Issue 7, Pages 1572-1581Publisher
MDPI AG
DOI: 10.3390/md10071572
Keywords
soft coral; Sinularia lochmodes; sesquiterpenes; aromadendrane; germacrane
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Funding
- National Science Council of the Republic of China [NSC 98-2113-M-110-002-MY3]
- Ministry of education [97C031702]
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Seven new sesquiterpenoids, lochmolins A-G (1-7), were isolated from a Taiwanese soft coral Sinularia lochmodes. The structures of these metabolites were elucidated by extensive spectroscopic study. Compounds 1-4 were found to inhibit the accumulation of the LPS-induced pro-inflammatory COX-2 protein in RAW264.7 macrophage cells.
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