Journal
MARINE DRUGS
Volume 10, Issue 5, Pages 1092-1102Publisher
MDPI
DOI: 10.3390/md10051092
Keywords
cell cycle arrest; ascidians; staurosporine
Categories
Funding
- CNPq
- CAPES
- InCB
- FAPESP
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The present study reports the identification of two new staurosporine derivatives, 2-hydroxy-7-oxostaurosporine (1) and 3-hydroxy-7-oxostaurosporine (2), obtained from mid-polar fractions of an aqueous methanol extract of the tunicate Eudistoma vannamei, endemic to the northeast coast of Brazil. The mixture of 1 and 2 displayed IC50 values in the nM range and was up to 14 times more cytotoxic than staurosporine across a panel of tumor cell lines, as evaluated using the MTT assay.
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