Journal
MARINE DRUGS
Volume 10, Issue 2, Pages 340-348Publisher
MDPI
DOI: 10.3390/md10020340
Keywords
marine fungus; Xylaria sp.; mangrove; sesquiterpenes; alpha-glucosidase
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Funding
- National Natural Science Foundation of China [20972197]
- Science & Technology Plan Project of Guangdong Province of China [2010B030600004]
- China's Marine Commonweal Research Project [201005022-2]
- Fundamental Research Funds for the Central Universities [101gpy11]
- Syngenta Ltd.
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Three new eremophilane sesquiterpenes (1-3) were isolated from the mangrove endophytic fungus Xylaria sp. BL321 together with 07H239-A (4), a known analogue of the new compounds. The structures of these compounds were elucidated by analysis of their MS, 1D and 2D NMR spectroscopic data. Compound 4 showed activation activity on alpha-glucosidase at 0.15 mu M (146%), and then, 4 gradually produced inhibitory activity on alpha-glucosidase with increasing concentration, and the IC50 value is 6.54 mu M.
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