Journal
MARINE DRUGS
Volume 10, Issue 10, Pages 2246-2253Publisher
MDPI
DOI: 10.3390/md10102246
Keywords
halimane; echinohalimane; Echinomuricea; cytotoxicity; elastase
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Funding
- National Museum of Marine Biology and Aquarium [100100101, 100200311]
- National Dong Hwa University
- Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University [00C-0302-05]
- National Science Council, Taiwan [NSC 101-2325-B-291-001, 101-2320-B-291-001-MY3]
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A new halimane-type diterpenoid, echinohalimane A (1), was isolated from a gorgonian, identified as Echinomuricea sp. The structure of 1 was determined by spectroscopic methods and this compound was found to exhibit cytotoxicity toward various tumor cells and display an inhibitory effect on the release of elastase by human neutrophils. Echinohalimane A (1) is the first halimane analogue from the marine organisms belonging to phylum Cnidaria.
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