Journal
MARINE DRUGS
Volume 10, Issue 1, Pages 131-139Publisher
MDPI AG
DOI: 10.3390/md10010131
Keywords
Sargassum thunbergii; Aspergillus versicolor; asperversin A; 9 xi-O-2(2,3-dimethylbut-3-enyl)brevianamide Q
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Funding
- National Natural Science Foundation of China [41106137, 41106136]
- Chinese Academy of Sciences [KZCX2-YW-QN209, KSCX2-EW-G-12B]
- Foundation of the Chinese Academy of Sciences
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Two new compounds, asperversin A (1) and 9 xi-O-2(2,3-dimethylbut-3-enyl)brevianamide Q (2), and nine known compounds, brevianamide K (3), brevianamide M (4), aversin (5), 6,8-di-O-methylnidurufin (6), 6,8-di-O-methylaverufin (7), 6-O-methylaverufin (8), 5 alpha,8 alpha-epidioxyergosta-6,22-dien-3 beta-ol (9), ergosta-7,22-diene-3 beta,5 alpha,6 beta-triol (10), and 6 beta-methoxyergosta-7,22-diene-3 beta,5 alpha-diol (11), were obtained from the culture of Aspergillus versicolor, an endophytic fungus isolated from the marine brown alga Sargassum thunbergii. The structures of these compounds were established by spectroscopic techniques. Compounds 4, 7 and 8 exhibited antibacterial activities against Escherichia coli and Staphyloccocus aureus, and 7 also showed lethality against brine shrimp (Artemia salina) with an LC(50) value of 0.5 mu g/mL.
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