Journal
MARINE DRUGS
Volume 10, Issue 6, Pages 1383-1390Publisher
MDPI AG
DOI: 10.3390/md10061383
Keywords
sterol sulfate; chlorine-containing steroid; Chalinula molitba; structure elucidation; PXR modulator
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Funding
- European Union [229893]
- MIUR, (PRIN) Sostanze ad attivita antitumorale: isolamento da fonti marine, sintesi di analoghi e ulteriore sviluppo della chemoteca LIBIOMOL, Rome, Italy
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Chalinulasterol (1) a new chlorinated sterol disulfate was isolated from the Caribbean sponge Chalinula molitba. Its structure was elucidated using mass spectrometry and NMR experiments. The possible role of chalinulasterol as modulator of the PXR nuclear receptor was investigated but, in spite of the close structural relationship with the PXR agonist solomonsterol A (2), it showed no activity. The structural requirements for the PXR nuclear receptor activity were discussed.
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