Journal
MARINE DRUGS
Volume 10, Issue 5, Pages 1156-1168Publisher
MDPI AG
DOI: 10.3390/md10051156
Keywords
briarenolide; briarane; Briareum; superoxide anion
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Funding
- National Museum of Marine Biology and Aquarium [100100101, 100200311]
- National Dong Hwa University: the Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University [00C-0302-05]
- Department of Health Clinical Trial and Research Center of Excellence [DOH101-TD-C-111-004]
- National Science Council, Taiwan [NSC 101-2325-B-291-001, 100-2325-B-291-001, 98-2320-B-291-001-MY3]
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Two new briarane diterpenoids, briarenolides, F (1) and G (2), were isolated from an octocoral identified as Briareum sp. The structures of briaranes 1 and 2 were established by spectroscopic methods and by comparison of the spectroscopic data with those of known briarane analogues. Briarenolide F was proven to be the first 6-hydroperoxybriarane derivative and this compound displayed a significant inhibitory effect on the generation of superoxide anion by human neutrophils.
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