Journal
MARINE DRUGS
Volume 10, Issue 3, Pages 668-676Publisher
MDPI AG
DOI: 10.3390/md10030668
Keywords
marine-derived actinomycete; Streptomyces lusitanus; antibacterial; antimycin B
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Funding
- CAS/SAFEA International Partnership program for Creative Research Teams [KZCXZ-YW-T001]
- Research Grants Council of the Hong Kong Special Administrative Region [N_HKUST602/09]
- China Ocean Mineral Resource Research and Development Association
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Two new antimycin A analogues, antimycin B1 and B2 (1-2), were isolated from a spent broth of a marine-derived bacterium, Streptomyces lusitanus. The structures of 1 and 2 were established on the basis of spectroscopic analyses and chemical methods. The isolated compounds were tested for their anti-bacterial potency. Compound 1 was found to be inactive against the bacteria Bacillus subtilis, Staphyloccocus aureus, and Loktanella hongkongensis. Compound 2 showed antibacterial activities against S. aureus and L. hongkongensis with MIC values of 32.0 and 8.0 mu g/mL, respectively.
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