Journal
MARINE DRUGS
Volume 10, Issue 2, Pages 497-508Publisher
MDPI AG
DOI: 10.3390/md10020497
Keywords
Penicillium sp.; deep sea sediment; sterol; spiroditerpenoids; cytotoxicity
Categories
Funding
- National Natural Science Foundation of China [30925039]
- Beijing Natural Science Foundation [5111003]
- Ministry of Science and Technology of China [2010ZX09401-403, 2012ZX09301-003]
- Chinese Academy of Sciences [KSCX2-EW-G-6]
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A new polyoxygenated sterol, sterolic acid (1), three new breviane spiroditerpenoids, breviones I-K (2-4), and the known breviones (5-8), were isolated from the crude extract of a Penicillium sp. obtained from a deep sea sediment sample that was collected at a depth of 5115 m. The structures of 1-4 were elucidated primarily by NMR experiments, and 1 was further confirmed by X-ray crystallography. The absolute configurations of 2 and 3 were deduced by comparison of their CD spectra with those of the model compounds. Compounds 2 and 5 showed significant cytotoxicity against MCF-7 cells, which is comparable to the positive control cisplatin.
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