Journal
MARINE DRUGS
Volume 11, Issue 1, Pages 33-39Publisher
MDPI AG
DOI: 10.3390/md11010033
Keywords
deep-sea sediment; actinomycete; Serinicoccus profundi sp nov.; alkaloid; antibacterial activity; cytotoxicity
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Funding
- FP7-People-IRSES (TCMCANCER Project) [230232]
- National High Technology Research and Development Program of China (863 Program) [2012AA092104]
- National Key Basic Research Program of China [2010CB833800, 2011CB915503]
- National Natural Science Foundation of China [41176148, 21002110, 20902094]
- Knowledge Innovation Program of Chinese Academy of Science [SQ200904, SQ201117]
- Ocean Public Welfare Scientific Research Project the State Oceanic Administration of China [201005022]
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One new alkaloid, 3-((6-methylpyrazin-2-yl)methyl)-1H-indole (1) was obtained from the deep-sea actinomycete Serinicoccus profundi sp. nov., along with five known compounds (2-6). Their structures were determined on the basis of detailed analysis of the 1D and 2D NMR as well as MS data. The new indole alkaloid displayed weak antimicrobial activity against Staphylococcus aureus ATCC 25923 with an MIC value of 96 mu g/mL. It showed no cytotoxicity on a normal human liver cell line (BEL7402) and a human liver tumor cell line (HL-7702).
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