4.7 Article

Five New Amicoumacins Isolated from a Marine-Derived Bacterium Bacillus subtilis

Journal

MARINE DRUGS
Volume 10, Issue 2, Pages 319-328

Publisher

MDPI AG
DOI: 10.3390/md10020319

Keywords

antibacterial; cytotoxicity; lipoamicoumacin; Bacillus subtilis

Funding

  1. King Abdullah University of Science and Technology (KAUST) [SA-C0040/UK-C001]

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Four novel amicoumacins, namely lipoamicoumacins A-D (1-4), and one new bacilosarcin analog (5) were isolated from culture broth of a marine-derived bacterium Bacillus subtilis, together with six known amicoumacins. Their structures were elucidated on the basis of extensive spectroscopic (2D NNR, IR, CD and MS) analysis and in comparison with data in literature.

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