Journal
MARINE DRUGS
Volume 9, Issue 6, Pages 994-1006Publisher
MDPI
DOI: 10.3390/md9060994
Keywords
soft coral; Sarcophyton crassocaule; cytotoxic activity; anti-inflammatory activity
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Funding
- Ministry of Education [98C031702]
- National Science Council of Taiwan [NSC 98-2113-M-110-002-MY3]
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Seven new cembranoids, sarcocrassocolides F-L (1-7), have been isolated from a soft coral Sarcophyton crassocaule. Their structures were determined by extensive spectroscopic analysis. Most new compounds exhibited significant cytotoxic activity against a limited panel of cancer cell lines, and the structure-activity relationship was studied. Compounds 1-7 were found to display significant in vitro anti-inflammatory activity in LPS-stimulated RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein. Compound 4 was also found to effectively reduce the level of COX-2 protein.
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