Journal
MARINE DRUGS
Volume 9, Issue 10, Pages 2131-2154Publisher
MDPI
DOI: 10.3390/md9102131
Keywords
marine sponges; marine natural products; protein kinase inhibitors; cell regulation; anticancer agents
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Funding
- University of Wollongong through the Centre for Medicinal Chemistry
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Protein kinases play a critical role in cell regulation and their deregulation is a contributing factor in an increasing list of diseases including cancer. Marine sponges have yielded over 70 novel compounds to date that exhibit significant inhibitory activity towards a range of protein kinases. These compounds, which belong to diverse structural classes, are reviewed herein, and ordered based upon the kinase that they inhibit. Relevant synthetic studies on the marine natural product kinase inhibitors have also been included.
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