Journal
MARINE DRUGS
Volume 9, Issue 4, Pages 535-542Publisher
MDPI AG
DOI: 10.3390/md9040535
Keywords
Spicaria elegans; high salt stress; secondary metabolites
Categories
Funding
- National Basic Research Program of China [2010CB833800]
- National Natural Science Foundation of China [30973680, 30670219]
- Special Fund for Marine Scientific Research in the Public Interest of China [2010418022-3]
- PCSIRT [IRT0944]
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To obtain structurally novel and bioactive natural compounds from marine-derived microorganisms, the effect of high salt stress on secondary metabolite production in the marine-derived fungal strain, Spicaria elegans KLA-03, was investigated. The organism, which was isolated from marine sediment, produced different secondary metabolites when cultured in 3% and 10% saline conditions. Four characteristic metabolites, only produced in the 10% salinity culture, were isolated, and their structures were identified as (2E, 2'Z)-3,3'-(6,6'-dihydroxybiphenyl-3,3'-diyl) diacrylic acid (1), aspulvinone E (2), aspochalasin E (3) and trichodermamide B (6), according to their 1D and 2D NMR spectra. Compound 1 is a new compound. High salt stress may therefore be a promising means to induce the production of new and chlorinated compounds in halotolerant fungi. Compound 1 showed moderate antibacterial activity against Pseudomonas aeruginosa and Escherichia coli with minimum inhibitory concentration (MIC) values of 0.038 and 0.767 mM, respectively.
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