Journal
MARINE DRUGS
Volume 9, Issue 9, Pages 1502-1509Publisher
MDPI AG
DOI: 10.3390/md9091502
Keywords
Streptomyces; anthracene; structure establishment; cytotoxicity
Categories
Funding
- CAS, Chinese Academy of Sciences [JQ200914, KSCX2-YW-G-073, KZCX2-YW-216, KZCX2-YW-209]
- National Natural Science Foundation of China [31000037]
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A new anthracene derivative, 3-hydroxy-1-keto-3-methyl-8-methoxy-1,2,3, 4-tetrahydro-benz[alpha]anthracene, was isolated from the marine strain Streptomyces sp. W007, and its structure was established by spectroscopic analysis including mass spectra, 1D- and 2D-NMR (H-1-H-1 COSY, HMBC, HSQC and NOESY) experiments. 3-hydroxy-1-keto-3-methyl-8-methoxy-1,2,3,4-tetrahydro-benz[alpha]anthracene showed cytotoxicity against human lung adenocarcinoma cell line A549.
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