Journal
MARINE DRUGS
Volume 9, Issue 5, Pages 879-888Publisher
MDPI
DOI: 10.3390/md9050879
Keywords
indole derivatives; bromoindoles; marine sponge; Rhopaloeides odorabile; Hyrtios sp.; PLA(2) inhibitor; antioxidant; cytotoxic
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Funding
- CRISP (Coral Reef Initiative in the South Pacific)
- Agence Fran aise de Developpement
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Indole derivatives including bromoindoles have been isolated from the South Pacific marine sponges Rhopaloeides odorabile and Hyrtios sp. Their structures were established through analysis of mass spectra and 1D and 2D NMR spectroscopic data. Their potential inhibitory phospholipase A(2) (PLA(2)), antioxidant and cytotoxic activities were evaluated. The new derivative 5,6-dibromo-L-hypaphorine (9) isolated from Hyrtios sp. revealed a weak bee venom PLA2 inhibition (IC50 0.2 mM) and a significant antioxidant activity with an Oxygen Radical Absorbance Capacity (ORAC) value of 0.22. The sesquiterpene aureol (4), also isolated from Hyrtios sp., showed the most potent antioxidant activity with an ORAC value of 0.29.
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