Journal
MARINE DRUGS
Volume 9, Issue 3, Pages 294-306Publisher
MDPI
DOI: 10.3390/md9030294
Keywords
Indonesian marine fungi; algicolous fungi; antifungal; bioactive compounds
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Funding
- German Academic Exchange Service (DAAD)
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In the search for bioactive compounds, 11 fungal strains were isolated from Indonesian marine habitats. Ethyl acetate extracts of their culture broth were tested for cytotoxic activity against a urinary bladder carcinoma cell line and for antifungal and antibacterial activities against fish and human pathogenic bacteria as well as against plant and human pathogenic fungi. The crude extract of a sterile algicolous fungus (KT31), isolated from the red seaweed Kappaphycus alvarezii (Doty) Doty ex P. C. Silva exhibited potent cytotoxic activity with an IC50 value of 1.5 mu g/mL. Another fungal strain (KT29) displayed fungicidal properties against the plant pathogenic fungus Cladosporium cucumerinum Ell. et Arth. at 50 mu g/spot. 2-Carboxy-8-methoxy-naphthalene-1-ol (1) could be isolated as a new natural product.
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