Journal
MARINE DRUGS
Volume 9, Issue 11, Pages 2220-2235Publisher
MDPI
DOI: 10.3390/md9112220
Keywords
Laurencia viridis; squalene; polyethers; cytotoxic activity
Categories
Funding
- EU [KBBE-3-245137]
- MICINN [CTQ2008-06754-C04-01, SAF2008-02251]
- ACISII [C2008000145, EXMAR]
- Red Tematica de Investigacion Cooperativa en Cancer [RD06/0020/1037]
- Instituto de Salud Carlos III
- Fondo Europeo de Desarrollo Regional of the European Union
- Junta de Castilla y Leon [CSI052A11-2]
- SEGAI-ULL
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The red seaweed Laurencia viridis is a rich source of secondary metabolites derived from squalene. New polyethers, such as iubol (2), 22-hydroxy-15(28)-dehydrovenustatriol (3), 1,2-dehydropseudodehydrothyrsiferol (4), and secodehydrothyrsiferol (5) have been isolated and characterized from this alga. The structures were determined through the interpretation of NMR spectroscopic data and the relative configuration was proposed on the basis of NOESY spectrum and biogenetic considerations. All new compounds exhibited significant cytotoxic activity against a panel of cancer cell lines.
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