Journal
MARINE DRUGS
Volume 9, Issue 2, Pages 162-183Publisher
MDPI AG
DOI: 10.3390/md9020162
Keywords
marine bryozoan; Cryptosula pallasiana; oxygenated sterols; cytotoxicity
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Funding
- National High-Tech Research and Development Project (863) [2007AA09Z401]
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Six new sterols (1-6), together with seven known sterols (7-13), were isolated from the CCl4 extract of the marine bryozoan Cryptosula pallasiana, four (3-6) of which have already been reported as synthetic sterols. This is the first time that these compounds (3-6) are reported as natural sterols. The structures of the new compounds were determined on the basis of the extensive spectroscopic analysis, including two-dimensional (2D) NMR and HR-ESI-MS data. Compounds 1-4, 7 and 10-13 were evaluated for their cytotoxicity against HL-60 human myeloid leukemia cell line, and all of the evaluated compounds exhibited moderate cytotoxicity to HL-60 cells with a range of IC50 values from 14.73 to 22.11 mu g/mL except for compounds 12 and 13.
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