4.7 Article

Menelloides C and D, New Sesquiterpenoids from the Gorgonian Coral Menella sp.

Journal

MARINE DRUGS
Volume 9, Issue 9, Pages 1534-1542

Publisher

MDPI AG
DOI: 10.3390/md9091534

Keywords

menelloide; lindenane; germacrane; sesquiterpenoid; Menella; elastase

Funding

  1. National Museum of Marine Biology and Aquarium [100100101, 100200311]
  2. National Dong Hwa University
  3. Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University [00C-0302-05]
  4. National Science Council, Taiwan [NSC 100-2325-B-291-001, 99-2323-B-291-001, 98-2320-B-291-001-MY3]

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Two new metabolites, including a lindenane-type sesquiterpenoid, menelloide C (1), and a germacrane-type sesquiterpenoid, menelloide D (2), were isolated from a Formosan gorgonian coral identified as Menella sp. The structures of 1 and 2 were established by spectroscopic methods and 2 displayed a weak inhibitory effect on the release of elastase by human neutrophils.

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