Journal
MARINE DRUGS
Volume 9, Issue 6, Pages 1157-1165Publisher
MDPI
DOI: 10.3390/md9061157
Keywords
ascidians; natural products; alkaloids; bioactive molecules; cytotoxic activity
Categories
Funding
- European Union [229893 (NatPharma)]
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Chemical analysis of the Mediterranean ascidian Polyandrocarpa zorritensis (Van Name 1931) resulted in the isolation of a series of molecules including two monoindole alkaloids, 3-indolylglyoxylic acid (3) and its methyl ester (4), 4-hydroxy-3-methoxyphenylglyoxylic acid methyl ester (1) and a new alkaloid we named zorrimidazolone (2). The structure of the novel compound 2 has been elucidated by spectroscopic analysis and bioactivity of all compounds has been investigated. Zorrimidazolone (2) showed a modest cytotoxic activity against C6 rat glioma cell line.
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