Journal
MARINE DRUGS
Volume 9, Issue 6, Pages 1133-1141Publisher
MDPI
DOI: 10.3390/md9061133
Keywords
marine cytotoxin; swinholide J; Theonella swinhoei
Categories
Funding
- Agence Francaise de Developpement
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In our ongoing search for new pharmacologically active leads from Solomon organisms, we have examined the sponge Theonella swinhoei. Herein we report the isolation and structure elucidation of swinholide A (1) and one new macrolide, swinholide J (2). Swinholide J is an unprecedented asymmetric 44-membered dilactone with an epoxide functionality in half of the molecule. The structural determination was based on extensive interpretation of high-field NMR spectra and HRESIMS data. Swinholide J displayed potent in vitro cytotoxicity against KB cells (human nasopharynx cancer) with an IC50 value of 6 nM.
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