Journal
MARINE DRUGS
Volume 9, Issue 12, Pages 2526-2536Publisher
MDPI AG
DOI: 10.3390/md9122526
Keywords
soft coral; Lobophytum crassum; cembranoids
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Funding
- National Museum of Marine Biology Aquarium
- National Science Council (NSC), Taiwan [100-2325-B-291-001]
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Three new cembranoids, culobophylins A-C (1-3), along with two known compounds (4 and 5) were isolated from the cultured soft coral Lobophytum crassum. The structures of these compounds were elucidated on the basis of their spectroscopic data and comparison of the NMR data with those of known analogues. Among these metabolites, 2 is rarely found in cembranoids possessing an isopropyl moiety with an epoxide group. Compound 1 exhibited significant cytotoxic activity against HL60 and DLD-1 cancer cell lines.
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