Journal
MARINE DRUGS
Volume 9, Issue 9, Pages 1477-1486Publisher
MDPI AG
DOI: 10.3390/md9091477
Keywords
Junceella fragilis; 8-hydroxybriarane; frajunolides; anti-inflammatory activities
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Funding
- National Science Council, Taiwan [NSC 98-2113-M-002-002-MY2]
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Four new 8-hydroxybriarane diterpenoids, frajunolides L-O (1-4), were isolated from the Taiwanese gorgonian Junceella fragilis. The structures of compounds 1-4 were elucidated based on spectroscopic analysis, especially 2D NMR ((1)H-(1)H COSY, HSQC, HMBC and NOESY) and HRMS. Compounds 1 and 4 showed weak anti-inflammatory activity as tested by superoxide anion generation and elastase release by human neutrophil in response to fMLP/CB. Compound 3 showed selective inhibition on elastase release in vitro.
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