Journal
MARINE DRUGS
Volume 9, Issue 3, Pages 359-368Publisher
MDPI
DOI: 10.3390/md9030359
Keywords
marine sponge; actinomycete; lobophorin C and D; cytotoxic activity
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Funding
- Zhejiang Ocean University
- Chinese Academy of Sciences [KSCX2-YW-G-073, KZCX2-YW-211-04]
- Natural Science Foundation of Zhejiang Province, China [20090782]
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Marine sponge Hymeniacidon sp. was collected from coastal waters of the East China Sea to isolate symbiotic microorganisms. The resulting sponge-associated actinomycete, Streptomyces carnosus strain AZS17, was cultivated in a 20 L volume of medium for production of bioactive secondary metabolites. Bioassay-guided isolation and purification by varied chromatographic methods yielded two new compounds of kijanimicin derivatives, AS7-2 and AS9-12. Their structures were elucidated by spectroscopy and comparison with literatures. Results showed these two compounds were structurally similar to the previously reported compounds lobophorin A and B, yet differed in specific bond forms, stereochemistry and optical activities. The two novel compounds were named lobophorin C and D. In vitro cytotoxicity investigation by MTT assay indicated their selective activities. Lobophorin C displayed potent cytotoxic activity against the human liver cancer cell line 7402, while lobophorin D showed significant inhibitory effect on human breast cancer cells MDA-MB 435.
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