Journal
MARINE DRUGS
Volume 9, Issue 1, Pages 98-108Publisher
MDPI
DOI: 10.3390/md9010098
Keywords
macrolide; Micromonospora; deep sea; natural product; marine
Categories
Funding
- European Union (EFRE)
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Two new 20-membered macrolides, levantilide A and B, were isolated from the Micromonospora strain M71-A77. Strain M71-A77 was recovered from an Eastern Mediterranean deep-sea sediment sample and revealed to produce the levantilides under in situ salinity of 38.6 parts per thousand. The chemical structures of the levantilides were elucidated on the basis of different one- and two- dimensional NMR experiments. Levantilide A exhibits a moderate antiproliferative activity against several tumor cell lines.
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