Journal
MARINE DRUGS
Volume 9, Issue 1, Pages 71-81Publisher
MDPI AG
DOI: 10.3390/md9010071
Keywords
natural product synthesis; marine bacteria; cyclic tetrapeptide; biological activity; Halisarca ectofibrosa; Diginea sp
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The first synthesis of a naturally occurring tetrapeptide cyclo-(isoleucyl-prolyl-leucyl-alanyl) has been achieved using a solution-phase technique via coupling of dipeptide segments Boc-L-Pro-L-Leu-OH and L-Ala-L-Ile-OMe. Deprotection of the linear tetrapeptide unit and its subsequent cyclization gave a cyclopeptide, identical in all aspects to the naturally occurring compound. Bioactivity results indicated the antifungal and antihelmintic potential of the synthesized peptide against pathogenic dermatophytes and earthworms.
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