Journal
MARINE DRUGS
Volume 8, Issue 6, Pages 1763-1768Publisher
MDPI
DOI: 10.3390/md8061763
Keywords
chitooligosaccharides; anti-inflammatory; animal model
Categories
Funding
- Fundacao para a Ciencia e a Tecnologia [SFRH/BD/31087/2006]
- CYTED [105PI0274]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/31087/2006] Funding Source: FCT
Ask authors/readers for more resources
All the reports to date on the anti-inflammatory activity of chitooligosaccharides (COS) are mostly based on in vitro methods. In this work, the anti-inflammatory activity of two COS mixtures is characterized in vivo (using balb/c mice), following the carrageenan-induced paw edema method. This is a widely accepted animal model of acute inflammation to evaluate the anti-inflammatory effect of drugs. Our data suggest that COS possess anti-inflammatory activity, which is dependent on dose and, at higher doses, also on the molecular weight. A single dose of 500 mg/kg b.w. weight may be suitable to treat acute inflammation cases; however, further studies are needed to ascertain the effect upon longer inflammation periods as well as studies upon the bioavailability of these compounds.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available