Journal
MARINE DRUGS
Volume 8, Issue 12, Pages 2936-2945Publisher
MDPI
DOI: 10.3390/md8122936
Keywords
cladielloide; eunicellin; octocoral; cytotoxicity; superoxide anion; elastase
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Funding
- National Museum of Marine Biology and Aquarium [99200321, 99200322]
- National Dong Hwa University
- Asia-Pacific Ocean Research Center, National Sun Yat-sen University [98C031702]
- National Science Council, Taiwan [NSC 99-2323-B-291-001, 98-2320-B-291-001-MY3]
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Two new eunicellin-type diterpenoids, cladielloides A (1) and B (2), which were found to possess a 2-hydroxybutyroxy group in their structures, were isolated from an Indonesian octocoral identified as Cladiella sp. The structures of eunicellins 1 and 2 were elucidated by spectroscopic methods. Cladielloide B (2) exhibited moderate cytotoxicity toward CCRF-CEM tumor cells and this compound displayed significant inhibitory effects on superoxide anion generation and elastase release by human neutrophils.
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