Journal
MARINE DRUGS
Volume 8, Issue 7, Pages 2014-2020Publisher
MDPI
DOI: 10.3390/md8072014
Keywords
Carijoa; carijoside; glycoside; superoxide anion; elastase; cytotoxicity
Categories
Funding
- NMMBA [99200321, 99200322]
- APORC, NSYSU [96C031702]
- NSTPBP, National Science Council, Taiwan [NSC 98-2323-B-291-001, 98-2320-B-291-001-MY3]
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A new bioactive sterol glycoside, 3 beta-O-(3',4'-di-O-acetyl-beta-D-arabinopyranosyl)-25 xi-cholestane-3 beta,5 alpha,6 beta,26-tetrol-26-acetate) (carijoside A, 1), was isolated from an octocoral identified as Carijoa sp. The structure of glycoside 1 was established by spectroscopic methods and by comparison with spectral data for the other known glycosides. Carijoside A (1) displayed significant inhibitory effects on superoxide anion generation and elastase release by human neutrophils and this compound exhibited moderate cytotoxicity toward DLD-1, P388D1, HL-60, and CCRF-CEM tumor cells.
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