Journal
MARINE DRUGS
Volume 8, Issue 6, Pages 1743-1749Publisher
MDPI
DOI: 10.3390/md8061743
Keywords
Laurencia sp.; halogenated metabolites; antibacterial activity
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Funding
- Sabah Parks
- International Foundation for Science (IFS) and Committee for the Prohibition of Chemical Weapon, Hague, The Netherlands (IFS) [AF/4286-2]
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In our continuous interest to study the diversity of halogenated metabolites of Malaysian species of the red algal genus Laurencia, we examined the chemical composition of five populations of unrecorded Laurencia sp. A new brominated diterpene, 10-acetoxyangasiol (1), and four other known metabolites, aplysidiol (2), cupalaurenol (3), 1-methyl-2,3,5-tribromoindole (4), and chamigrane epoxide (5), were isolated and identified. Isolated metabolites exhibited potent antibacterial activities against clinical bacteria, Staphylococcus aureus, Staphylococcus sp., Streptococcus pyogenes, Salmonella sp. and Vibrio cholerae.
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