Journal
MARINE DRUGS
Volume 8, Issue 11, Pages 2744-2754Publisher
MDPI
DOI: 10.3390/md8112744
Keywords
marine fungus; Penicillium aurantiogriseum; verrucosidin
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Funding
- National 863 Project [2007AA09Z443]
- Key Project for International Cooperation [2007DFB31620]
- National Natural Science Foundation of China [30973665, 30700015, 30901849, 30911120484, 81011120046, 30911120483]
- National Key Technology RD Program [2007BAI26B02]
- CAS [KSCX2-YW-R-164]
- Important National Science & Technology Specific Projects [2008ZX09401-05, 2009ZX09302-004]
- Hundred Talents Program
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The new secondary metabolites verrucosidinol (1) and its derivative verrucosidinol acetate (2), together with a potent neurotoxin verrucosidin (3), a congener norverrucosidin (4) and a mixture of two known phytotoxic metabolites terrestric acids (5 and 6), were isolated from the marine derived fungus Penicillium aurantiogriseum. Verrucosidinol has a ring-opened ethylene oxide moiety in the polyene alpha-pyrone skeleton, and verrucosidinol acetate is its acetate derivative. The chemical structures were determined by comparing with literature data and a combination of spectroscopic techniques, including high resolution mass spectrum and two-dimentional nuclear magnetic resonance spectroscopic analysis.
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