Journal
MARINE DRUGS
Volume 7, Issue 4, Pages 754-786Publisher
MDPI AG
DOI: 10.3390/md7040754
Keywords
granulatimide; isogranulatimide; pyrrolocarbazole; indolocarbazole; kinase inhibitor
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Granulatimide and isogranulatimide are alkaloids obtained from marine sources which have been shown to inhibit cell-cycle G2-checkpoint, targeting more particularly checkpoint 1 kinase (Chk1). At a structural level, they possess a characteristic pyrrolocarbazole framework also shared by the well-known rebeccamycin and staurosporine microbial metabolites which have been described to inhibit topoisomerase I and diverse kinases, respectively. This review reports precisely on the synthesis and kinase inhibitory activities of pyrrolocarbazole-based analogues of granulatimide.
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