Journal
MARINE DRUGS
Volume 7, Issue 3, Pages 435-444Publisher
MDPI
DOI: 10.3390/md7030435
Keywords
Jaspis splendens; jaspamide Q and R; structure elucidation; cytotoxic activity
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Funding
- Egyptian Government (Ministry of High Education)
- BMBF
- MOST
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Two new jaspamide derivatives 2 and 3, together with the parent compound jaspamide (1) have been isolated from the marine sponge Jaspis splendens collected in Kalimantan (Indonesia). The structures of the new compounds were unambiguously elucidated based on 1D and 2D NMR spectral data, mass spectrometry and comparison with jaspamide (1). The new derivatives inhibited the growth of mouse lymphoma (L5178Y) cell line in vitro with IC50 values of < 0.1 mu g/mL.
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